Emergence and Persistence of Collective Cell Migration on Small Circular Micropatterns

Abstract

The spontaneous formation of vortices is a hallmark of collective cellular activity. Here, we study the onset and persistence of coherent angular motion (CAMo) as a function of the number of cells $N$ confined in circular micropatterns. We find that the persistence of CAMo increases with $N$ but exhibits a pronounced discontinuity accompanied by a geometric rearrangement of cells to a configuration containing a central cell. Computer simulations based on a generalized Potts model reproduce the emergence of vortex states and show in agreement with experiment that their stability depends on the interplay of spatial arrangement and internal polarization of neighboring cells. Hence, the distinct migrational states in finite size ensembles reveal significant insight into the local interaction rules guiding collective migration.

arXiv comment5 pages, 4 figures

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• Polar Fluctuations Lead to Extensile Nematic Behavior in Confluent Tissues
• Defect Spirograph: Dynamical Behavior of Defects in Spatially Patterned Active Nematics
• Controlling topological defects and contractile flow in confined nematic cell population
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• Gaussian theory for spatially distributed self-propelled particles
• Mean-field equation for a stochastic many-particle model of quorum-sensing microbial populations
• Topological defects in polar active matter
• Morphology, Polarization Patterns, Compression, and Entropy Production in Phase-Separating Active Dumbbell Systems