A TB-HIV/AIDS coinfection model and optimal control treatment

Abstract

We propose a population model for TB-HIV/AIDS coinfection transmission dynamics, which considers antiretroviral therapy for HIV infection and treatments for latent and active tuberculosis. The HIV-only and TB-only sub-models are analyzed separately, as well as the TB-HIV/AIDS full model. The respective basic reproduction numbers are computed, equilibria and stability are studied. Optimal control theory is applied to the TB-HIV/AIDS model and optimal treatment strategies for co-infected individuals with HIV and TB are derived. Numerical simulations to the optimal control problem show that non intuitive measures can lead to the reduction of the number of individuals with active TB and AIDS.

This is a preprint of a paper whose final and definite form will be published in the journal 'Discrete and Continuous Dynamical Systems. Series A', ISSN 1078-0947 (Print), ISSN 1553-5231 (Online). Submitted 03/May/2014; revised 08/Nov/2014 and 23/Nov/2014; accepted 14/Jan/2015. arXiv admin note: text overlap with arXiv:1406.0877

References in corpus (3)

• Cost effectiveness analysis of optimal control measures for tuberculosis
• Dynamics of Dengue epidemics using optimal control
• Optimal control strategies for tuberculosis treatment: a case study in Angola

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