On the kinetics that moves Myosin V
arXiv:1412.6689 · doi:10.1016/j.physa.2015.05.071
Abstract
Molecular motor proteins such as Myosin V, Dynein or Kinesin are no ratchets, at least not with a flashing asymmetric potential; the crucial asymmetry is in the dynamical activity. We make that explicit in terms of a simple Markov model, emphasizing the kinetic (and non-thermodynamic) aspects of stochastic transport. The analysis shows the presence of a fluctuation symmetry in that part of the dynamical activity which is antisymmetric under reversal of trailing and leading head of the motor. The direction of the motor motion is determined by it.
14 pages and 2 figures
References in corpus (5)
- First-order dynamical phase transition in models of glasses: an approach based on ensembles of histories
- Frenetic aspects of second order response
- Dynamical phase transitions in supercooled liquids: interpreting measurements of dynamical activity
- Low temperature behavior of nonequilibrium multilevel systems
- Two theorems that relate discrete stochastic processes to microscopic mechanics