Single-cell analysis of growth in budding yeast and bacteria reveals a common size regulation strategy
arXiv:1410.4771 · doi:10.1016/j.cub.2015.11.067
Abstract
To maintain a constant cell size, dividing cells have to coordinate cell cycle events with cell growth. This coordination has for long been supposed to rely on the existence of size thresholds determining cell cycle progression [1]. In budding yeast, size is controlled at the G1/S transition [11]. In agreement with this hypothesis, the size at birth influences the time spent in G1: smaller cells have a longer G1 period [3]. Nevertheless, even though cells born smaller have a longer G1, the compensation is imperfect and they still bud at smaller cell sizes. In bacteria, several recent studies have shown that the incremental model of size control, in which size is controlled by addition of a constant volume (in contrast to a size threshold), is able to quantitatively explain the experimental data on 4 different bacterial species [6, 5, 6, 7]. Here, we report on experimental results for the budding yeast Saccharomyces cerevisiae, finding, surprisingly, that cell size control in this organism is very well described by the incremental model, suggesting a common strategy for cell size control with bacteria. Additionally, we argue that for S. cerevisiae the volume increment is not added from birth to division, but rather between two budding events.
References in corpus (3)
Cited by in corpus (19)
- Interrogating the Escherichia coli cell cycle by cell dimension perturbations
- Individuality and universality in the growth-division laws of single E. coli cells
- Individuality and slow dynamics in bacterial growth homeostasis
- Non-genetic inheritance restraint of cell-to-cell variation
- Robust replication initiation from coupled homeostatic mechanisms
- Relevant parameters in models of cell division control
- From single-cell variability to population growth
- Stochastic modeling of cell growth with symmetric or asymmetric division
- Details Matter: noise and model structure set the relationship between cell size and cell cycle timing
- Reassessment of the basis of cell size control based on analysis of cell-to-cell variability
- Models of protein production along the cell cycle: an investigation of possible sources of noise
- Non-genetic variability: survival strategy or nuisance?
- Stochastic Maps, Continuous Approximation and Stable Distribution
- From noisy cell size control to population growth: when variability can be beneficial
- Cell lineage statistics with incomplete population trees
- Modeling cell size regulation: From single-cell level statistics to molecular mechanisms and population level effects
- Multiplicative noise underlies Taylor's law in protein concentration fluctuations in single cells
- Exactly Solvable Population Model with Square-Root Growth Noise and Cell-Size Regulation
- How does variability in cells aging and growth rates influence the malthus parameter?