A new diamond biosensor with integrated graphitic microchannels for detecting quantal exocytic events from chromaffin cells
arXiv:1308.6412 · doi:10.1002/adma.201300710
Abstract
The quantal release of catecholamines from neuroendocrine cells is a key mechanism which has been investigated with a broad range of materials and devices, among which carbon-based materials such as carbon fibers, diamond-like carbon, carbon nanotubes and nanocrystalline diamond. In the present work we demonstrate that a MeV-ion-microbeam lithographic technique can be successfully employed for the fabrication of an all-carbon miniaturized cellular bio-sensor based on graphitic micro-channels embedded in a single-crystal diamond matrix. The device was functionally characterized for the in vitro recording of quantal exocytic events from single chromaffin cells, with high sensitivity and signal-to-noise ratio, opening promising perspectives for the realization of monolithic all-carbon cellular biosensors.
References in corpus (4)
- Direct fabrication of three-dimensional buried conductive channels in single crystal diamond with ion microbeam induced graphitization
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Cited by in corpus (14)
- Inscription of 3D waveguides in diamond using an ultrafast laser
- Electrical control of deep NV centers in diamond by means of sub-superficial graphitic micro-electrodes
- Microelectrode arrays of diamond-insulated graphitic channels for real time detection of exocytotic events from cultured chromaffin cells and slices of adrenal glands
- All-carbon multi-electrode array for real-time in vitro measurements of oxidizable neurotransmitters
- Electrical stimulation of single-photon emission from nitrogen-vacancy centers in diamond with sub-superficial graphitic electrodes
- Realization of a diamond based high density multi electrode array by means of deep ion beam lithography
- Development and characterization of a diamond-insulated graphitic multi electrode array realized with ion beam lithography
- High resolution structural characterisation of laser-induced defect clusters inside diamond
- Effects of high-power laser irradiation on sub-superficial graphitic layers in single crystal diamond
- Electroluminescence from a diamond device with ion-beam-micromachined buried graphitic electrodes
- An analytical model for the mechanical deformation of locally graphitized diamond
- Kelvin probe characterization of buried graphitic microchannels in single-crystal diamond
- Micro-beam and pulsed laser beam techniques for the micro-fabrication of diamond surface and bulk structures
- Enhancing the Study of Quantal Exocytotic Events: Combining Diamond Multi-Electrode Arrays with Amperometric PEak Analysis (APE) an Automated Analysis Code