The waiting time for a second mutation: an alternative to the Moran model
arXiv:1306.6919 · doi:10.1016/j.physa.2014.01.031
Abstract
The appearance of cancer in a tissue is thought to be the result of two or more successive mutations. We propose a stochastic model that allows for an exact computation of the distribution of the waiting time for a second mutation. This models the time of appearance of the first cancerous cell in a tissue. Our model is an alternative to the Moran model with mutations.