A waiting time problem arising from the study of multi-stage carcinogenesis

Abstract

We consider the population genetics problem: how long does it take before some member of the population has $m$ specified mutations? The case $m=2$ is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger $m$ are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.

Published in at http://dx.doi.org/10.1214/08-AAP559 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org)

References in corpus (2)

• Waiting for regulatory sequences to appear
• The waiting time for m mutations

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