Electrophoresis of a DNA Coil Near a Nanopore

Abstract

Motivated by DNA electrophoresis near a nanopore, we consider the flow field around an "elongated jet", a long thin source which injects momentum into a liquid. This solution qualitatively describes the electro-osmotic flow around a long rigid polymer, where due to electrohydrodynamic coupling, the solvent receives momentum from the electric field. Based on the qualitative behavior of the elongated jet solution, we develop a coarse-grained scheme which reproduces the known theoretical results regarding the electrophoretic behavior of a long rigid polymer and a polymer coil in a uniform field, which we then exploit to analyze the electrophoresis of a polymer coil in the non-uniform field near a nanopore.

10 pages, 4 figures

References in corpus (1)

• Entropic force of polymers on a cone tip

Cited by in corpus (6)

• Role of Non-Equilibrium Conformations on Driven Polymer Translocation
• DNA capture into the ClyA nanopore: diffusion-limited versus reaction-limited processes
• Controlling Polymer Capture and Translocation by Electrostatic Polymer-Pore Interactions
• Enhanced polymer capture speed and extended translocation time in pressure-solvation traps
• An efficient Kinetic Monte Carlo to study analyte capture by a nanopore: Transients, boundary conditions and time-dependent fields
• Electrophoretic Mobility of Polyelectrolytes within a Confining Well