paper

Role of HIV RNA structure in recombination and speciation: romping in purine A, keeps HTLV away

arXiv:1305.2132 · doi:10.1016/j.micinf.2013.10.017

Abstract

Extreme enrichment of the human immunodeficiency virus (HIV-1) RNA genome for the purine A parallels the mild purine-loading of the RNAs of most organisms. This should militate against loop-loop "kissing" interactions between the structured viral genome and structured host RNAs, which can generate segments of double-stranded RNA sufficient to trigger intracellular alarms. However, human T cell leukaemia virus (HTLV-1), with the potential to invade the same host cell, shows extreme enrichment for the pyrimidine C. Assuming the low GC% HIV and the high GC% HTLV-1 to share a common ancestor, it was postulated that differences in GC% arose to prevent homologous recombination between these emerging lentiviral species. Sympatrically isolated by this intracellular reproductive barrier, prototypic HIV-1 seized the AU-rich (low GC%) high ground (thus committing to purine A rather than purine G). Prototypic HTLV-1 forwent this advantage and evolved an independent evolutionary strategy. Evidence supporting this hypothesis since its elaboration in the 1990s is growing. The conflict between the needs to encode accurately both a protein, and nucleic acid structure, is often resolved in favour of the nucleic acid because, apart from regulatory roles, structure is critical for recombination. However, above a sequence difference threshold, structure (and hence recombination) is impaired. New species can then arise.

Initially submitted to the Journal of Theoretical Biology 27th November 2012

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