Subdiffraction-limited quantum imaging within a living cell
arXiv:1305.1353 · doi:10.1103/PhysRevX.4.011017
Abstract
We report both sub-diffraction-limited quantum metrology and quantum enhanced spatial resolution for the first time in a biological context. Nanoparticles are tracked with quantum correlated light as they diffuse through an extended region of a living cell in a quantum enhanced photonic force microscope. This allows spatial structure within the cell to be mapped at length scales down to 10 nm. Control experiments in water show a 14% resolution enhancement compared to experiments with coherent light. Our results confirm the longstanding prediction that quantum correlated light can enhance spatial resolution at the nanoscale and in biology. Combined with state-of-the-art quantum light sources, this technique provides a path towards an order of magnitude improvement in resolution over similar classical imaging techniques.
References in corpus (7)
- Nanometer scale quantum thermometry in a living cell
- Experimental realization of sub-shot-noise quantum imaging
- Experimental realisation of quantum illumination
- An Entanglement-Enhanced Microscope
- Detection of atomic spin labels in a lipid bi-layer using a single-spin nanodiamond probe
- Quantum Imaging beyond the Diffraction Limit by Optical Centroid Measurements
- Optical lock-in particle tracking in optical tweezers
Cited by in corpus (29)
- Real applications of quantum imaging
- A Geometric Perspective on Quantum Parameter Estimation
- Beating Abbe diffraction limit in confocal microscopy via non-classical photon statistics
- Photon number correlation for quantum enhanced imaging and sensing
- Quantum imaging with sub-Poissonian light: challenges and perspectives in optical metrology
- Quantum interferometer combining squeezing and parametric amplification
- Resonance fluorescence from an artificial atom in squeezed vacuum
- Retrieving ideal precision in noisy quantum optical metrology
- Truncated nonlinear interferometry for quantum enhanced atomic force microscopy
- Observation of localized multi-spatial-mode quadrature squeezing in four-wave mixing
- Quantum metrology in local dissipative environments
- Attaining sub-classical metrology in lossy systems with entangled coherent states
- Quantum sensing of open systems: Estimation of damping constants and temperature
- Super-resolution Optical Fluctuation Imaging -- fundamental estimation theory perspective
- Precision Measurements Using Squeezed Spin States via Two-axis Counter-twisting Interactions
- Heralded generation of entanglement with photons
- Quantum enhanced estimation of diffusion
- Quantum super-resolution microscopy by photon statistics and structured light
- Interaction-free imaging of multi-pixel objects
- Classification of spin and multipolar squeezing
- Non-Markovian effect on quantum optical metrology under dissipative environment
- Transmission Estimation at the Fundamental Quantum Cramér-Rao Bound with Macroscopic Quantum Light
- Noncritical generation of nonclassical frequency combs via spontaneous rotational symmetry breaking
- Nonclassical states of light with a smooth function
- Parallel Quantum-Enhanced Sensing
- Beam focusing and reduction of quantum uncertainty in width at the few-photon level via multi-spatial-mode squeezing
- Weakly invasive metrology: quantum advantage and physical implementations
- Quantum metrology of a structured reservoir
- Quantum Simulation of Bound-State-Enhanced Quantum Metrology