Anatomical MRI with an atomic magnetometer

Abstract

Ultra-low field (ULF) MRI is a promising method for inexpensive medical imaging with various additional advantages over conventional instruments such as low weight, low power, portability, absence of artifacts from metals, and high contrast. Anatomical ULF MRI has been successfully implemented with SQUIDs, but SQUIDs have the drawback of cryogen requirement. Atomic magnetometers have sensitivity comparable to SQUIDs and can be in principle used for ULF MRI to replace SQUIDs. Unfortunately some problems exist due to the sensitivity of atomic magnetometers to magnetic field and gradients. At low frequency, noise is also substantial and a shielded room is needed for improving sensitivity. In this paper, we show that at 85 kHz, the atomic magnetometer can be used to obtain anatomical images. This is the first demonstration of any use of atomic magnetometers for anatomical MRI. The demonstrated resolution is 1.1x1.4 mm2 in about six minutes of acquisition with SNR of 10. Some applications of the method are discussed. With several measures it is also possible to increase sensitivity to reach resolution 1x1 mm2, which is typical in medical imaging.

References in corpus (4)

• NMR detection with an atomic magnetometer
• Microtesla MRI of the human brain combined with MEG
• Detection of NMR signals with a radio-frequency atomic magnetometer
• Parallel MRI at microtesla fields

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• Restoring Narrow Linewidth to a Gradient-Broadened Magnetic Resonance by Inhomogeneous Dressing
• Sensitivity of Proposed Search for Axion-induced Magnetic Field using Optically Pumped Magnetometers
• Time-resolved diamond magnetic microscopy of superparamagnetic iron-oxide nanoparticles
• Zero- to ultralow-field nuclear magnetic resonance and its applications
• Local, mm-scale ${}^1$H magnetic resonance imaging using atomic vapors