Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion
arXiv:1207.2575 · doi:10.1209/0295-5075/99/38003
Abstract
We analyze the stability of micro-domains of ligand-receptor bonds that mediate the adhesion of biological model membranes. After evaluating the effects of membrane fluctuations on the binding affinity of a single bond, we characterize the organization of bonds within the domains by theoretical means. In a large range of parameters, we find the commonly suggested dense packing to be separated by a free energy barrier from a regime in which bonds are sparsely distributed. If bonds are mobile, a coexistence of the two regimes should emerge, which agrees with recent experimental observations.
arXiv comment6 pages, 6 figures, accepted by EPL
References in corpus (7)
- Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes
- Indirect interactions of membrane-adsorbed cylinders
- Adhesion of membranes with competing specific and generic interactions
- Adhesion-Induced Lateral Phase Separation in Membranes
- Specific Adhesion of Membranes: Mapping to an Effective Bond Lattice Gas
- Membrane fluctuations near a plane rigid surface
- Non-monotonic fluctuation spectra of membranes pinned or tethered discretely to a substrate
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