Specific Adhesion of Membranes: Mapping to an Effective Bond Lattice Gas

Abstract

We theoretically consider specific adhesion of a fluctuating membrane to a hard substrate via the formation of bonds between receptors attached to the substrate and ligands in the membrane. By integrating out the degrees of freedom of the membrane shape, we show that in the biologically relevant limit specific adhesion is well described by a lattice gas model, where lattice sites correspond to bond sites. We derive an explicit expression for the effective bond interactions induced by the thermal undulations of the membrane. Furthermore, we compare kinetic Monte Carlo simulations for our lattice gas model with full dynamic simulations that take into account both the shape fluctuations of the membrane and reactions between receptors and ligands at bond sites. We demonstrate that an appropriate mapping of the height dependent binding and unbinding rates in the full scheme to rates in the lattice gas model leads to good agreement.

References in corpus (5)

• Ligand-Receptor Interactions
• Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes
• Adhesion of membranes with competing specific and generic interactions
• Hybrid simulations of lateral diffusion in fluctuating membranes
• The unbinding transition of mixed fluid membranes

Cited by in corpus (8)

• Multiscale approaches to protein-mediated interactions between membranes - Relating microscopic and macroscopic dynamics in radially growing adhesions
• Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion
• Diffusion of active tracers in fluctuating fields
• Random pinning limits the size of membrane adhesion domains
• Criticality in Cell Adhesion
• Statistical mechanics of an elastically pinned membrane: Static profile and correlations
• Effective free energy for pinned membranes
• Lattice models for protein organization throughout thylakoid membrane stacks