Probing active forces via a fluctuation-dissipation relation: Application to living cells

Abstract

We derive a new fluctuation-dissipation relation for non-equilibrium systems with long-term memory. We show how this relation allows one to access new experimental information regarding active forces in living cells that cannot otherwise be accessed. For a silica bead attached to the wall of a living cell, we identify a crossover time between thermally controlled fluctuations and those produced by the active forces. We show that the probe position is eventually slaved to the underlying random drive produced by the so-called active forces.

5 pages

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• Universal thermodynamic bounds on nonequilibrium response with biochemical applications
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• Generalized Langevin Equation with Hydrodynamic Backflow: Equilibrium Properties
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• Distribution of active forces in the cell cortex
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