Base Pair Openings and Temperature Dependence of DNA Flexibility

Abstract

The relationship of base pair openings to DNA flexibility is examined. Published experimental data on the temperature dependence of the persistence length by two different groups are well described in terms of an inhomogeneous Kratky-Porot model with soft and hard joints, corresponding to open and closed base pairs, and sequence-dependent statistical information about the state of each pair provided by a Peyrard-Bishop-Dauxois (PBD) model calculation with no freely adjustable parameters.

References in corpus (5)

• The thermal denaturation of DNA studied with neutron scattering
• Melting of genomic DNA: predictive modeling by nonlinear lattice dynamics
• Temperature dependence of circular DNA topological states
• Bubbles, clusters and denaturation in genomic DNA: modeling, parametrization, efficient computation
• On 4-point correlation functions in simple polymer models

Cited by in corpus (8)

• Flexibility of short DNA helices with finite-length effect: from base pairs to tens of base pairs
• Single molecule study of the DNA denaturation phase transition in the force-torsion space
• Bending stiff charged polymers: the electrostatic persistence length
• Tension-induced binding of semiflexible biopolymers
• Elasticity of cross-linked semiflexible biopolymers under tension
• Tensile elasticity of semiflexible polymers with hinge defects
• Rigidity of Melting DNA
• On the thermodynamics of DNA in the Peyrard-Bishop-Dauxois model