Influence of direct motor-motor interaction in models for cargo transport by a single team of motors

Abstract

We analyze theoretically the effects of excluded-volume interactions between motors on the dynamics of a cargo driven by multiple motors. The model considered shares many commons with other recently proposed in the literature, with the addition of direct interaction between motors and motor back steps. The cargo is assumed to follow a continuum Langevin dynamics, while individual motors evolve following a Monte Carlo algorithm based on experimentally accessible probabilities for discrete forward and backward jumps, and attachment and detachment rates. The links between cargo and motors are considered as non linear springs. By means of numerical simulations we compute the relevant quantities characterizing the dynamical properties of the system, and we compare the results to those for non interacting motors. We find that interactions lead to quite relevant changes in the force-velocity relation for cargo, with a considerable reduction of the stall force, and cause also a notable decrease of the run length. These effects are mainly due to traffic-like phenomena in the microtubule. The consideration of several parallel tracks for motors reduces such effects. However, we find that for realistic values of the number of motors and the number of tracks, the influence of interactions on the global parameters of transport of cargo are far from being negligible. Our studies provide also an analysis of the relevance of motor back steps on the modeling, and of the influence of different assumptions for the detachment rates. In particular, we discuss these two aspects in connection with the possibility of observing processive back motion of cargo at large load forces.

arXiv comment33 pages, 14 figures

References in corpus (6)

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• Effectiveness of a dynein team in tug-of-war helped by reduced load-sensitivity of detachment: evidence from study of bidirectional endosome transport in Dictyostelium discoideum
• Motility states in bidirectional cargo transport
• Sufficient conditions for the additivity of stall forces generated by multiple filaments or motors
• Stall force of a cargo driven by N interacting motor proteins
• Two Heads Are (Sometimes) Better Than One: How Rate Formulations Impact Molecular Motor Dynamics