Lattice-gas model for active vesicle transport by molecular motors with opposite polarities

Abstract

We introduce a multi-species lattice gas model for motor protein driven collective cargo transport on cellular filaments. We use this model to describe and analyze the collective motion of interacting vesicle cargoes being carried by oppositely directed molecular motors, moving on a single biofilament. Building on a totally asymmetric exclusion process (TASEP) to characterize the motion of the interacting cargoes, we allow for mass exchange with the environment, input and output at filament boundaries and focus on the role of interconversion rates and how they affect the directionality of the net cargo transport. We quantify the effect of the various different competing processes in terms of non-equilibrium phase diagrams. The interplay of interconversion rates, which allow for flux reversal and evaporation/deposition processes introduce qualitatively new features in the phase diagrams. We observe regimes of three-phase coexistence, the possibility of phase re-entrance and a significant flexibility in how the different phase boundaries shift in response to changes in control parameters. The moving steady state solutions of this model allows for different possibilities for the spatial distribution of cargo vesicles, ranging from homogeneous distribution of vesicles to polarized distributions, characterized by inhomogeneities or {\it shocks}. Current reversals due to internal regulation emerge naturally within the framework of this model. We believe this minimal model will clarify the understanding of many features of collective vesicle transport, apart from serving as the basis for building more exact quantitative models for vesicle transport relevant to various {\it in-vivo} situations.

References in corpus (6)

• Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors
• Phase Coexistence in Driven One Dimensional Transport
• Cooperative Cargo Transport by Several Molecular Motors
• The Totally Asymmetric Simple Exclusion Process with Langmuir Kinetics
• Phase transitions in systems with two species of molecular motors
• Dynamics of an exclusion process with creation and annihilation

Cited by in corpus (10)

• Intracellular transport driven by cytoskeletal motors: General mechanisms and defects
• Phase segregation and transport in a two species multi-lane system
• Collective transport of weakly interacting molecular motors with Langmuir kinetics
• Jamming transition in a driven lattice gas
• Interference of two co-directional exclusion processes in the presence of a static bottleneck: a biologically motivated model
• A Multispecies Exclusion Process with Fusion and Fission of Rods: a model inspired by Intraflagellar Transport
• A Multispecies Exclusion Model Inspired By Transcriptional Interference
• A biologically motivated three-species exclusion model: effects of leaky scanning and overlapping genes on initiation of protein synthesis
• Driven Transport on open filaments with inter-filament switching processes
• Current reversals in driven lattice gases and Brownian motion