Effect of Bending Anisotropy on the 3D Conformation of Short DNA Loops
arXiv:0811.3315 · doi:10.1103/PhysRevLett.101.168103
Abstract
The equilibrium three dimensional shape of relatively short loops of DNA is studied using an elastic model that takes into account anisotropy in bending rigidities. Using a reasonable estimate for the anisotropy, it is found that cyclized DNA with lengths that are not integer multiples of the pitch take on nontrivial shapes that involve bending out of planes and formation of kinks. The effect of sequence inhomogeneity on the shape of DNA is addressed, and shown to enhance the geometrical features. These findings could shed some light on the role of DNA conformation in protein--DNA interactions.
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Cited by in corpus (9)
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- Twist-bend coupling and the torsional response of double-stranded DNA
- Bend-Induced Twist Waves and the Structure of Nucleosomal DNA
- Buckling of stiff polymer rings in weak spherical confinement
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