Effects of the chemomechanical stepping cycle on the traffic of molecular motors

Abstract

We discuss effects of the stepping kinetics of molecular motors on their traffic behavior on crowded filaments using a simple two-state chemomechanical cycle. While the general traffic behavior is quite robust with respect to the detailed kinetics of the step, a few observable parameters exhibit a strong dependence on these parameters. Most strikingly, the effective unbinding rate of the motors may both increase and decrease with increasing traffic density, depending on the details of the motor step. Likewise the run length either exhibits a strong decrease or almost no dependence on the traffic density. We compare our theoretical results with recent experimental observations on motor traffic.

arXiv comment14 pages, 3 figures

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• Deciphering mRNA Sequence Determinants of Protein Production Rate
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• Power series solution of the inhomogeneous exclusion process
• Minimal model of transcriptional elongation processes with pauses
• Stepping and crowding of molecular motors: statistical kinetics from an exclusion process perspective
• Maximum power operation of interacting molecular motors
• Transport by molecular motors in the presence of static defects
• Traffic Jams and Shocks of Molecular Motors inside Cellular Protrusions
• Efficiency at maximum power of motor traffic on networks
• Current-density relation in the exclusion process with dynamic obstacles
• Microtubule length dependence of motor traffic in cells
• 3-state Hamiltonians associated to solvable 33-vertex models
• Spontaneous Spatiotemporal Ordering of Shape Oscillations Enhances Cell Migration
• Exclusion process subject to conformational size changes