Critical evaluation of the computational methods used in the forced polymer translocation

Abstract

In forced polymer translocation, the average translocation time, $\tau$, scales with respect to pore force, $f$, and polymer length, $N$, as $\tau \sim f^{-1}{N}^{\beta }$. We demonstrate that an artifact in Metropolis Monte Carlo method resulting in breakage of the force scaling with large $f$ may be responsible for some of the controversies between different computationally obtained results and also between computational and experimental results. Using Langevin dynamics simulations we show that the scaling exponent $\beta \le 1+\nu$ is not universal, but depends on $f$. Moreover, we show that forced translocation can be described by a relatively simple force balance argument and $\beta$ to arise solely from the initial polymer configuration.

References in corpus (4)

• Langevin Dynamics Simulations of Polymer Translocation through Nanopores
• Polymer translocation through a nanopore - a showcase of anomalous diffusion
• Driven polymer translocation through a nanopore: a manifestation of anomalous diffusion
• Quantized current blockade and hydrodynamic correlations in biopolymer translocation through nanopores: evidence from multiscale simulations

Cited by in corpus (1)

• Dynamics of forced biopolymer translocation