Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer invasion via extracellular signal-regulated kinase 2

Ruchi Malik, Tiffany Luong, Xuan Cao +6

Only about 8 percent of patients with pancreatic ductal adenocarcinoma, PDAC, live up to 5 years following diagnosis; by 2020 PDAC will become the second most lethal cancer in the…