226 citations
- Feinstein Institute for Medical ResearchUS26 papers
- University of Science and Technology of ChinaCN6 papers
- Hofstra UniversityUS4 papers
- Universidad Nacional Autónoma de MéxicoMX4 papers
- National Centre of Scientific Research "Demokritos"GR3 papers
- Zucker Hillside HospitalUS3 papers
- Columbia UniversityUS2 papers
- Stony Brook UniversityUS2 papers
- AIRI - Artificial Intelligence Research InstituteRU1 paper
- Aristotle University of ThessalonikiGR1 paper
- Athena Research and Innovation Center In Information Communication & Knowledge TechnologiesGR1 paper
- Barcelona Supercomputing CenterES1 paper
8 papers · 1 filter
Revisiting the Neutral Dynamics Derived Limiting Guanine-Cytosine Content Using the Human De Novo Point Mutation Data
Wentian Li, Yannis Almirantis, Astero Provata
We revisit the topic of human genome guanine-cytosine content under neutral evolution. For this study, the de novo mutation data within human is used to estimate mutational rate in…
Quantifying Local Randomness in Human DNA and RNA Sequences Using Erdos Motifs
Wentian Li, Dimitrios Thanos, Astero Provata
In 1932, Paul Erdos asked whether a random walk constructed from a binary sequence can achieve the lowest possible deviation (lowest discrepancy), for the sequence itself and for a…
Diminishing Return for Increased Mappability with Longer Sequencing Reads: Implications of the k-mer Distributions in the Human Genome
Wentian Li, Jan Freudenberg, Pedro Miramontes
The amount of non-unique sequence (non-singletons) in a genome directly affects the difficulty of read alignment to a reference assembly for high throughput-sequencing data. Althou…
Partial correlation analysis indicates causal relationships between GC-content, exon density and recombination rate in the human genome
Jan Freudengerb, Mingyi Wang, Yaning Yang +1
{\bf Background}: Several features are known to correlate with the GC-content in the human genome, including recombination rate, gene density and distance to telomere. However, by…
Copy-number-variation and copy-number-alteration region detection by cumulative plots
Wentian Li, Annette Lee, Peter K Gregersen
Background: Regions with copy number variations (in germline cells) or copy number alteration (in somatic cells) are of great interest for human disease gene mapping and cancer stu…
Two-Parameter Characterization of Chromosome-Scale Recombination Rate
Wentian Li, Jan Freudenberg
The genome-wide recombination rate () of a species is often described by one parameter, the ratio between total genetic map length () and physical map length (), measured…