Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis

Carsten Baldauf, Reinhard Schneppenheim, Wolfram Stacklies +5

To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a she…