93 citations
6 papers
Empirical Bayes estimation of posterior probabilities of enrichment
Zhenyu Yang, Zuojing Li, David R. Bickel
To interpret differentially expressed genes or other discovered features, researchers conduct hypothesis tests to determine which biological categories such as those of the Gene On…
Resolving conflicts between statistical methods by probability combination: Application to empirical Bayes analyses of genomic data
David R. Bickel
In the typical analysis of a data set, a single method is selected for statistical reporting even when equally applicable methods yield very different results. Examples of equally…
Gene Expression Noise Facilitates Adaptation and Drug Resistance Independently of Mutation
Daniel A. Charlebois, Nezar Abdennur, Mads Kaern
We show that the effect of stress on the reproductive fitness of noisy cell populations can be modelled as first-passage time problem, and demonstrate that even relatively short-li…
An Algorithm for the Stochastic Simulation of Gene Expression and Heterogeneous Population Dynamics
Daniel A. Charlebois, Jukka Intosalmi, Dawn Fraser +1
We present an algorithm for the stochastic simulation of gene expression and heterogeneous population dynamics. The algorithm combines an exact method to simulate molecular-level f…
Controlling the degree of caution in statistical inference with the Bayesian and frequentist approaches as opposite extremes
David R. Bickel
In statistical practice, whether a Bayesian or frequentist approach is used in inference depends not only on the availability of prior information but also on the attitude taken to…
Simple estimators of false discovery rates given as few as one or two p-values without strong parametric assumptions
David R. Bickel
Multiple comparison procedures that control a family-wise error rate or false discovery rate provide an achieved error rate as the adjusted p-value for each hypothesis tested. Howe…