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4 papers · 1 filter
Direct-coupling analysis of residue co-evolution captures native contacts across many protein families
Faruck Morcos, Andrea Pagnani, Bryan Lunt +7
The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting co…
3D Protein Structure Predicted from Sequence
Debora S. Marks, Lucy J. Colwell, Robert Sheridan +4
The evolutionary trajectory of a protein through sequence space is constrained by function and three-dimensional (3D) structure. Residues in spatial proximity tend to co-evolve, ye…
A Quantitative Test of Population Genetics Using Spatio-Genetic Patterns in Bacterial Colonies
Kirill S. Korolev, Joao B. Xavier, David R. Nelson +1
It is widely accepted that population genetics theory is the cornerstone of evolutionary analyses. Empirical tests of the theory, however, are challenging because of the complex re…
Universality in Bacterial Colonies
Juan A. Bonachela, Carey D. Nadell, Joao B. Xavier +1
The emergent spatial patterns generated by growing bacterial colonies have been the focus of intense study in physics during the last twenty years. Both experimental and theoretica…