39 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- Chicago Department of Public HealthUS3 papers
- University of ChicagoUS3 papers
- Colorado State UniversityUS1 paper
- East China Normal UniversityCN1 paper
- Fudan UniversityCN1 paper
- Galena Biopharma (United States)US1 paper
- Genesys (United States)US1 paper
- Institut Polytechnique de BordeauxFR1 paper
- McMaster UniversityCA1 paper
- StormGeo (Norway)NO1 paper
- The University of Texas at AustinUS1 paper
- University of TorontoCA1 paper
3 papers · 1 filter
Pharmacometrics-Enabled DOse OPtimization (PEDOOP) for Seamless Phase I-II Trials in Oncology
Shijie Yuan, Zhanbo Huang, Jiaxin Liu +1
We consider a dose-optimization design for first-in-human oncology trial that aims to identify a suitable dose for late-phase drug development. The proposed approach, called the Ph…
The Backfill i3+3 Design for Dose-Finding Trials in Oncology
Jiaxin Liu, Shijie Yuan, B. Nebiyou Bekele +1
We consider a formal statistical design that allows simultaneous enrollment of a main cohort and a backfill cohort of patients in a dose-finding trial. The goal is to accumulate mo…
The Ci3+3 Design for Dual-Agent Combination Dose-Finding Clinical Trials
Shijie Yuan, Tianjian Zhou, Yawen Lin +1
We propose a rule-based statistical design for combination dose-finding trials with two agents. The Ci3+3 design is an extension of the i3+3 design with simple decision rules compa…