52 citations
- University of ChicagoUS7 papers
- The University of Texas at AustinUS4 papers
- Cytel (United States)US3 papers
- University of Illinois ChicagoUS3 papers
- Colorado State UniversityUS2 papers
- Fudan UniversityCN2 papers
- Cancer Research And BiostatisticsUS1 paper
- East China Normal UniversityCN1 paper
- Florida International UniversityUS1 paper
- Galena Biopharma (United States)US1 paper
- Georgia Institute of TechnologyUS1 paper
- Harvard UniversityUS1 paper
12 papers
Monitoring Adverse Events Through Bayesian Nonparametric Clustering Across Studies
Shijie Yuan, Kevin Roberts, Noirrit Kiran Chandra +2
We introduce a Bayesian nonparametric inference approach for aggregate adverse event (AE) monitoring across studies. The proposed model seamlessly integrates external data from his…
SIMBA -- A Bayesian Decision Framework for the Identification of Optimal Biomarker Subgroups for Cancer Basket Clinical Trials
Shijie Yuan, Jiaxin Liu, Zhihua Gong +4
We consider basket trials in which a biomarker-targeting drug may be efficacious for patients across different disease indications. Patients are enrolled if their cells exhibit som…
VIGMA: An Open-Access Framework for Visual Gait and Motion Analytics
Kazi Shahrukh Omar, Shuaijie Wang, Ridhuparan Kungumaraju +2
Gait disorders are commonly observed in older adults, who frequently experience various issues related to walking. Additionally, researchers and clinicians extensively investigate…
Pharmacometrics-Enabled DOse OPtimization (PEDOOP) for Seamless Phase I-II Trials in Oncology
Shijie Yuan, Zhanbo Huang, Jiaxin Liu +1
We consider a dose-optimization design for first-in-human oncology trial that aims to identify a suitable dose for late-phase drug development. The proposed approach, called the Ph…
On adjustment for temperature in heatwave epidemiology: a new method and toward clarification of methods to estimate health effects of heatwaves
Honghyok Kim, Michelle Bell
Defining the effect of exposure of interest and selecting an appropriate estimation method are prerequisite for causal inference. Understanding the ways in which association betwee…
The Backfill i3+3 Design for Dose-Finding Trials in Oncology
Jiaxin Liu, Shijie Yuan, B. Nebiyou Bekele +1
We consider a formal statistical design that allows simultaneous enrollment of a main cohort and a backfill cohort of patients in a dose-finding trial. The goal is to accumulate mo…