21 citations
3 papers
physics.flu-dyn2023★ 9 cited
In vitro evaluation of solution-based pressurised metered dose inhaler sprays with low GWP propellants
Daniel Duke, Lingzhe Rao, Benjamin Myatt +4
BACKGROUND: The impending transition from high Global Warming Potential (GWP) propellants such as HFA134a to low-GWP alternatives such as HFA152a and HFO1234ze(E) in pressurised me…
physics.flu-dyn2023★ 6 cited
Canister valve and actuator deposition in metered dose inhalers formulated with low-GWP propellants
Daniel J Duke, Lingzhe Rao, Alan Kastengren +6
A challenge in pressurised metered-dose inhaler formulation design is management of adhesion of the drug to the canister wall, valve and actuator internal components and surfaces,…
q-bio.TO2021★ 21 cited
Harnessing subcellular-resolved organ distribution of cationic copolymer-functionalized fluorescent nanodiamonds for optimal delivery of therapeutic siRNA to a xenografted tumor in mice
Sandra Claveau, Marek Kindermann, Alexandre Papine +9
Diamond nanoparticles (nanodiamonds) can transport active drugs in cultured cells as well as in vivo. However, in the latter case, methods allowing to determine their bioavailabili…