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stat.ME2021
A unified framework for weighted parametric group sequential design (WPGSD)
Keaven M. Anderson, Zifang Guo, Jing Zhao +1
Group sequential design (GSD) is widely used in clinical trials in which correlated tests of multiple hypotheses are used. Multiple primary objectives resulting in tests with known…
stat.ME2020
A Nonparametric Method for Value Function Guided Subgroup Identification via Gradient Tree Boosting for Censored Survival Data
Pingye Zhang, Junshui Ma, Xinqun Chen +1
In randomized clinical trials with survival outcome, there has been an increasing interest in subgroup identification based on baseline genomic, proteomic markers or clinical chara…
stat.ME2020
Survival Analysis Using a 5-Step Stratified Testing and Amalgamation Routine in Randomized Clinical Trials
Devan V. Mehrotra, Rachel Marceau West
Randomized clinical trials are often designed to assess whether a test treatment prolongs survival relative to a control treatment. Increased patient heterogeneity, while desirable…