3 papers
stat.ME2021
A unified framework for weighted parametric group sequential design (WPGSD)
Keaven M. Anderson, Zifang Guo, Jing Zhao +1
Group sequential design (GSD) is widely used in clinical trials in which correlated tests of multiple hypotheses are used. Multiple primary objectives resulting in tests with known…
stat.AP2021
Independent Action Models and Prediction of Combination Treatment Effects for Response Rate, Duration of Response and Tumor Size Change in Oncology Drug Development
Linda Z. Sun, Cai, Wu +4
An unprecedented number of new cancer targets are in development, and most are being developed in combination therapies. Early oncology development is strategically challenged in c…
stat.ME2020
Multiplicity for a Group Sequential Trial with Biomarker Subpopulations
Ting-Yu Chen, Jing Zhao, Linda Sun +1
Biomarker subpopulations have become increasingly important for drug development in targeted therapies. The use of biomarkers has the potential to facilitate more effective outcome…