66 citations
- Chalmers University of TechnologySE8 papers
- AstraZeneca (United Kingdom)GB4 papers
- Lund UniversitySE3 papers
- Centre National de la Recherche ScientifiqueFR2 papers
- Helmholtz MunichDE2 papers
- Leiden UniversityNL2 papers
- Target (Germany)DE2 papers
- University of CambridgeGB2 papers
- University of GothenburgSE2 papers
- AstraZeneca (Finland)FI1 paper
- AstraZeneca (Germany)DE1 paper
- AstraZeneca (Netherlands)NL1 paper
25 papers
ZeroFold: Protein-RNA Binding Affinity Predictions from Pre-Structural Embeddings
Josef Hanke, Sebastian Pujalte Ojeda, Shengyu Zhang +3
The accurate prediction of protein-RNA binding affinity remains an unsolved problem in structural biology, limiting opportunities in understanding gene regulation and designing RNA…
Why the Northern Hemisphere Needs a 30-40 m Telescope and the Science at Stake: Resolved Stellar Populations Studies in M31 and its Satellites
C. Gallart, E. Fernández-Alvar, A. B. A. Queiroz +48
A 30 m class optical/near-IR telescope in the Northern Hemisphere, equipped for diffraction-limited imaging and high-resolution, multi-object spectroscopy of faint stars, would ena…
PerfCam: Digital Twinning for Production Lines Using 3D Gaussian Splatting and Vision Models
Michel Gokan Khan, Renan Guarese, Fabian Johnson +6
We introduce PerfCam, an open source Proof-of-Concept (PoC) digital twinning framework that combines camera and sensory data with 3D Gaussian Splatting and computer vision models f…
Publishing Neural Networks in Drug Discovery Might Compromise Training Data Privacy
Fabian P. Krüger, Johan Östman, Lewis Mervin +2
This study investigates the risks of exposing confidential chemical structures when machine learning models trained on these structures are made publicly available. We use membersh…
Modeling PROTAC Degradation Activity with Machine Learning
Stefano Ribes, Eva Nittinger, Christian Tyrchan +1
PROTACs are a promising therapeutic modality that harnesses the cell's built-in degradation machinery to degrade specific proteins. Despite their potential, developing new PROTACs…
Orbital dynamics in galactic potentials under mass transfer
Eduárd Illés, Dániel Jánosi, Tamás Kovács
Time-dependent potentials are common in galactic systems that undergo significant evolution, interactions, or encounters with other galaxies, or when there are dynamic processes li…