66 citations
- Chalmers University of TechnologySE9 papers
- AstraZeneca (United Kingdom)GB4 papers
- Lund UniversitySE3 papers
- Centre National de la Recherche ScientifiqueFR2 papers
- Helmholtz MunichDE2 papers
- Leiden UniversityNL2 papers
- Medical University of ViennaAT2 papers
- Novartis (Switzerland)CH2 papers
- Target (Germany)DE2 papers
- University of CambridgeGB2 papers
- University of GothenburgSE2 papers
- AstraZeneca (Finland)FI1 paper
4 papers · 1 filter
Extracting quantitative biological information from brightfield cell images using deep learning
Saga Helgadottir, Benjamin Midtvedt, Jesús Pineda +5
Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell struct…
Design Of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization
Francesco Bosica, Sebastian Andrei, João Filipe Neves +5
The protein-protein interactions (PPIs) of 14-3-3 proteins are a model system for studying PPI stabilization. The complex natural product Fusicoccin A stabilizes many 14-3-3 PPIs b…
Benchmarking the Variational Quantum Eigensolver through Simulation of the Ground State Energy of Prebiotic Molecules on High-Performance Computers
P. Lolur, M. Rahm, M. Skogh +2
We use the Variational Quantum Eigensolver (VQE) as implemented in the Qiskit software package to compute the ground state energy of small molecules derived from water, HO, and…
A modified weighted log-rank test for confirmatory trials with a high proportion of treatment switching
José L. Jiménez, Julia Niewczas, Alexander Bore +1
In confirmatory cancer clinical trials, overall survival (OS) is normally a primary endpoint in the intention-to-treat (ITT) analysis under regulatory standards. After the tumor pr…