output
20012020
most citedThe efficiency of multi-target drugs: the network approach might help drug design

813 citations

7 papers

cs.IR2020★ 16 cited

COVID-19Base: A knowledgebase to explore biomedical entities related to COVID-19

Junaed Younus Khan, Md. Tawkat Islam Khondaker, Iram Tazim Hoque +4

We are presenting COVID-19Base, a knowledgebase highlighting the biomedical entities related to COVID-19 disease based on literature mining. To develop COVID-19Base, we mine the in…

q-bio.MN2014

Analysis of the hierarchical structure of the B. subtilis transcriptional regulatory network

Santhust Kumar, Michele Vendruscolo, Amit Singh +2

The transcriptional regulation of gene expression is orchestrated by complex networks of interacting genes. Increasing evidence indicates that these transcriptional regulatory netw…

q-bio.MN2009★ 25 cited

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function

Virendra K. Chaudhri, Dhiraj Kumar, Manjari Misra +2

We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphata…

q-bio.MN2004★ 813 cited

The efficiency of multi-target drugs: the network approach might help drug design

Peter Csermely, Vilmos Agoston, Sandor Pongor

Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increas…

q-bio.MN2004★ 111 cited

Multiple, weak hits confuse complex systems: A transcriptional regulatory network as an example

Vilmos Agoston, Peter Csermely, Sandor Pongor

Robust systems, like the molecular networks of living cells are often resistant to single hits such as those caused by high-specificity drugs. Here we show that partial weakening o…

physics.bio-ph2001★ 53 cited

The coherent dynamics of photoexcited green fluorescent proteins

Riccardo A. G. Cinelli, Valentina Tozzini, Vittorio Pellegrini +6

The coherent dynamics of vibronic wave packets in the green fluorescent protein is reported. At room temperature the non-stationary dynamics following impulsive photoexcitation dis…