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q-bio.GN2005
Substantial regional variation in substitution rates in the human genome: importance of GC content, gene density and telomere-specific effects
Peter F Arndt, Terence Hwa, Dmitri A Petrov
This study presents the first global, 1 Mbp level analysis of patterns of nucleotide substitutions along the human lineage. The study is based on the analysis of a large amount of…
q-bio.GN2005
Identification and Measurement of Neighbor Dependent Nucleotide Substitution Processes
Peter F. Arndt, Terence Hwa
The presence of neighbor dependencies generated a specific pattern of dinucleotide frequencies in all organisms. Especially, the CpG-methylation-deamination process is the predomin…
q-bio.GN2005★ 55 cited
A Solvable Sequence Evolution Model and Genomic Correlations
Philipp W. Messer, Peter F. Arndt, Michael Lässig
We study a minimal model for genome evolution whose elementary processes are single site mutation, duplication and deletion of sequence regions and insertion of random segments. Th…