641 citations
- Massachusetts General HospitalUS73 papers
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5 papers · 1 filter
Cancer Cell Motility: Optimizing Spatial Search Strategies
L. Leon Chen, Le Zhang, Jeongah Yoon +1
Aberrantly regulated cell motility is a hallmark of cancer cells. A hybrid agent-based model has been developed to investigate the synergistic and antagonistic cell motility-impact…
Multi-Scale, Multi-Resolution Brain Cancer Modeling
Le Zhang, L. Leon Chen, Thomas S. Deisboeck
In advancing discrete-based computational cancer models towards clinical applications, one faces the dilemma of how to deal with an ever growing amount of biomedical data that ough…
Simulating non-small cell lung cancer with a multiscale agent-based model
Zhihui Wang, Le Zhang, Jonathan Sagotsky +1
Background The epidermal growth factor receptor (EGFR) is frequently overexpressed in many cancers, including non-small cell lung cancer (NSCLC). In silcio modeling is considered t…
The Effects of EGF-Receptor Density on Multiscale Tumor Growth Patterns
Chaitanya A. Athale, Thomas S. Deisboeck
We studied the effects of epidermal growth factor receptor (EGFR) density on tumor growth dynamics, both on the sub- and the multi-cellular level using our previously developed mod…
Simulating the Impact of a Molecular 'Decision-Process' on Cellular Phenotype and Multicellular Patterns in Brain Tumors
Chaitanya Athale, Yuri Mansury, Thomas S. Deisboeck
Experimental evidence indicates that human brain cancer cells proliferate or migrate, yet do not display both phenotypes at the same time. Here, we present a novel computational mo…