2.6k citations
- University of CopenhagenDK3 papers
- Brown UniversityUS1 paper
- Helmholtz MunichDE1 paper
- Michigan State UniversityUS1 paper
- Michigan UnitedUS1 paper
- Novo Nordisk (Denmark)DK1 paper
- Novo Nordisk (United States)US1 paper
- Novozymes (United States)US1 paper
- Pacific Northwest National LaboratoryUS1 paper
- Saint Louis UniversityUS1 paper
- Southern Methodist UniversityUS1 paper
- Technical University of DenmarkDK1 paper
Showing 2012Show all
2 papers · 1 filter
q-bio.BM2012★ 12 cited
In silico screening of 393 mutants facilitates enzyme engineering of amidase activity in CalB
Martin R. Hediger, Luca De Vico, Julie B. Rannes +4
Our previously presented method for high throughput computational screening of mutant activity (Hediger et al., arXiv:1203.2950) is benchmarked against experimentally measured amid…
physics.chem-ph2012★ 25 cited
A Computational Methodology to Screen Activities of Enzyme Variants
Martin R. Hediger, Luca De Vico, Allan Svendsen +2
We present a fast computational method to efficiently screen enzyme activity. In the presented method, the effect of mutations on the barrier height of an enzyme-catalysed reaction…