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q-bio.MN2007★ 21 cited
Cancer systems biology: exploring cancer-associated genes on cellular networks
Edwin Wang, Anne Lenferink, Maureen O'Connor-McCourt
Genomic alterations lead to cancer complexity and form a major hurdle for a comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we descr…
q-bio.MN2005★ 46 cited
Self-organization of gene regulatory network motifs enriched with short transcript's half-life transcription factors
Edwin Wang, Enrico Purisima
Network motifs, the recurring regulatory structural patterns in networks, are able to self-organize to produce networks. Three major motifs, feedforward loop, single input modules…