132 citations
3 papers
q-bio.MN2007★ 21 cited
Cancer systems biology: exploring cancer-associated genes on cellular networks
Edwin Wang, Anne Lenferink, Maureen O'Connor-McCourt
Genomic alterations lead to cancer complexity and form a major hurdle for a comprehensive understanding of the molecular mechanisms underlying oncogenesis. In this review, we descr…
q-bio.GN2006★ 132 cited
MicroRNAs preferentially target the genes with high transcriptional regulation complexity
Qinghua Cui, Zhenbao Yu, Youlian Pan +2
Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the g…
q-bio.MN2005★ 46 cited
Self-organization of gene regulatory network motifs enriched with short transcript's half-life transcription factors
Edwin Wang, Enrico Purisima
Network motifs, the recurring regulatory structural patterns in networks, are able to self-organize to produce networks. Three major motifs, feedforward loop, single input modules…