17 citations
2 papers
stat.ME2020★ 1 cited
Optimal Bayesian hierarchical model to accelerate the development of tissue-agnostic drugs and basket trials
Liyun Jiang, Lei Nie, Fangrong Yan +1
Tissue-agnostic trials enroll patients based on their genetic biomarkers, not tumor type, in an attempt to determine if a new drug can successfully treat disease conditions based o…
stat.AP2015★ 17 cited
The use of covariates and random effects in evaluating predictive biomarkers under a potential outcome framework
Zhiwei Zhang, Lei Nie, Guoxing Soon +1
Predictive or treatment selection biomarkers are usually evaluated in a subgroup or regression analysis with focus on the treatment-by-marker interaction. Under a potential outcome…