50 citations
- Centre National de la Recherche ScientifiqueFR5 papers
- Université d'Évry Val-d'EssonneFR4 papers
- Commissariat à l'Énergie Atomique et aux Énergies AlternativesFR2 papers
- Institut de Physique ThéoriqueFR2 papers
- Université Paris-SaclayFR2 papers
- Beijing Computational Science Research CenterCN1 paper
- Biologie cellulaire et CancerFR1 paper
- CAPSID: Computational Algorithms for Protein Structures and InteractionsFR1 paper
- CEA Paris-SaclayFR1 paper
- Centre for Genomic RegulationES1 paper
- Centre Inria de l'Université de LorraineFR1 paper
- École Nationale Supérieure d’Informatique pour l’Industrie et l’EntrepriseFR1 paper
5 papers
A polymer model for the quantitative reconstruction of 3d chromosome architecture from Hi-C and GAM data
Guillaume Le Treut, François Képès, Henri Orland
It is widely believed that the folding of the chromosome in the nucleus has a major effect on genetic expression. For example co-regulated genes in several species have been shown…
Phase behaviour of DNA in presence of DNA-binding proteins
Guillaume Le Treut, François Képès, Henri Orland
To characterize the thermodynamical equilibrium of DNA chains interacting with a solution of non-specific binding proteins, a Flory-Huggins free energy model was implemented. We ex…
A model for gene deregulation detection using expression data
Thomas Picchetti, Julien Chiquet, Mohamed Elati +3
In tumoral cells, gene regulation mechanisms are severely altered, and these modifications in the regulations may be characteristic of different subtypes of cancer. However, these…
Mining Representative Unsubstituted Graph Patterns Using Prior Similarity Matrix
Wajdi Dhifli, Rabie Saidi, Engelbert Mephu Nguifo
One of the most powerful techniques to study protein structures is to look for recurrent fragments (also called substructures or spatial motifs), then use them as patterns to chara…
CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus
Ivan Junier, Ryan Dale, Chunhui Hou +2
The principles underlying the architectural landscape of chromatin beyond the nucleosome level in living cells remains largely unknown despite its potential to play a role in mamma…