1.5k citations
- University of California, San FranciscoUS3 papers
- Cornell UniversityUS2 papers
- Harvard UniversityUS2 papers
- National Institutes of HealthUS2 papers
- University College LondonGB2 papers
- University of California, BerkeleyUS2 papers
- University of ChicagoUS2 papers
- University of PittsburghUS2 papers
- 23andMe (United States)US1 paper
- Academy of Sciences Republic of UzbekistanUZ1 paper
- Aix-Marseille UniversitéFR1 paper
- Al Akhawayn UniversityMA1 paper
6 papers
Mapping Differential Protein-Protein Interaction Networks using Affinity Purification Mass Spectrometry
Prashant Kaushal, Manisha R. Ummadi, Gwendolyn M. Jang +14
Proteins congregate into complexes to perform fundamental cellular functions. Phenotypic outcomes, in health and disease, are often mechanistically driven by the remodeling of prot…
Current and future directions in network biology
Marinka Zitnik, Michelle M. Li, Aydin Wells +34
Network biology is an interdisciplinary field bridging computational and biological sciences that has proved pivotal in advancing the understanding of cellular functions and diseas…
Bayesian Estimation of Population-Level Trends in Measures of Health Status
Mariel M. Finucane, Christopher J. Paciorek, Goodarz Danaei +1
Improving health worldwide will require rigorous quantification of population-level trends in health status. However, global-level surveys are not available, forcing researchers to…
Ancient human genomes suggest three ancestral populations for present-day Europeans
Iosif Lazaridis, Nick Patterson, Alissa Mittnik +117
We sequenced genomes from a 7,000 year old early farmer from Stuttgart in Germany, an 8,000 year old hunter-gatherer from Luxembourg, and seven 8,000 year old hun…
Integrating diverse datasets improves developmental enhancer prediction
Genevieve D. Erwin, Rebecca M. Truty, Dennis Kostka +2
Gene-regulatory enhancers have been identified by many lines of evidence, including evolutionary conservation, regulatory protein binding, chromatin modifications, and DNA sequence…
A Model-Based Analysis of GC-Biased Gene Conversion in the Human and Chimpanzee Genomes
John A. Capra, Melissa J. Hubisz, Dennis Kostka +2
GC-biased gene conversion (gBGC) is a recombination-associated process that favors the fixation of G/C alleles over A/T alleles. In mammals, gBGC is hypothesized to contribute to v…