818 citations
- Erasmus University RotterdamNL40 papers
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6 papers · 1 filter
Disease Progression and Subtype Modeling for Combined Discrete and Continuous Input Data
Sterre de Jonge, Elisabeth J. Vinke, Meike W. Vernooij +3
Disease progression modeling provides a robust framework to identify long-term disease trajectories from short-term biomarker data. It is a valuable tool to gain a deeper understan…
MyDigiTwin: A Privacy-Preserving Framework for Personalized Cardiovascular Risk Prediction and Scenario Exploration
Héctor Cadavid, Hyunho Mo, Bauke Arends +5
Cardiovascular disease (CVD) remains a leading cause of death, and primary prevention through personalized interventions is crucial. This paper introduces MyDigiTwin, a framework t…
Handling missing values in healthcare data: A systematic review of deep learning-based imputation techniques
Mingxuan Liu, Siqi Li, Han Yuan +7
Objective: The proper handling of missing values is critical to delivering reliable estimates and decisions, especially in high-stakes fields such as clinical research. The increas…
Federated Learning Enables Big Data for Rare Cancer Boundary Detection
Sarthak Pati, Ujjwal Baid, Brandon Edwards +276
Although machine learning (ML) has shown promise in numerous domains, there are concerns about generalizability to out-of-sample data. This is currently addressed by centrally shar…
Event-Based Modeling with High-Dimensional Imaging Biomarkers for Estimating Spatial Progression of Dementia
Vikram Venkatraghavan, Florian Dubost, Esther E. Bron +3
Event-based models (EBM) are a class of disease progression models that can be used to estimate temporal ordering of neuropathological changes from cross-sectional data. Current EB…
Disease Progression Timeline Estimation for Alzheimer's Disease using Discriminative Event Based Modeling
Vikram Venkatraghavan, Esther E. Bron, Wiro J. Niessen +1
Alzheimer's Disease (AD) is characterized by a cascade of biomarkers becoming abnormal, the pathophysiology of which is very complex and largely unknown. Event-based modeling (EBM)…