119 citations
Counting papers with at most 25 authors, so collaboration author lists do not stand in for the people here.
- The University of Texas at San AntonioUS5 papers
- The University of Texas Health Science Center at HoustonUS3 papers
- Cedars-Sinai Medical CenterUS2 papers
- InsermFR2 papers
- Northwestern Polytechnical UniversityCN2 papers
- Stanford UniversityUS2 papers
- The University of Texas Southwestern Medical CenterUS2 papers
- University of California, Los AngelesUS2 papers
- University of California San DiegoUS2 papers
- Aarhus University HospitalDK1 paper
- Academy of AthensGR1 paper
- Ain Shams University HospitalEG1 paper
20 papers
KMT2B-related disorders: expansion of the phenotypic spectrum and long-term efficacy of deep brain stimulation
L Cif, D Demailly, JP Lin +112
Heterozygous mutations in KMT2B are associated with an early-onset, progressive, and often complex dystonia (DYT28). Key characteristics of typical disease include focal motor feat…
Vision-Language and Large Language Model Performance in Gastroenterology: GPT, Claude, Llama, Phi, Mistral, Gemma, and Quantized Models
Seyed Amir Ahmad Safavi-Naini, Shuhaib Ali, Omer Shahab +15
Background and Aims: This study evaluates the medical reasoning performance of large language models (LLMs) and vision language models (VLMs) in gastroenterology. Methods: We used…
Accommodating heterogeneous missing data patterns for prostate cancer risk prediction
Matthias Neumair, Michael W. Kattan, Stephen J. Freedland +13
Objective: We compared six commonly used logistic regression methods for accommodating missing risk factor data from multiple heterogeneous cohorts, in which some cohorts do not co…
Reproducibility and Evolution of Diffusion MRI Measurements within the Cervical Spinal Cord in Multiple Sclerosis
Haykel Snoussi, Emmanuel Caruyer, Benoit Combes +5
In Multiple Sclerosis (MS), there is a large discrepancy between the clinical observations and how the pathology is exhibited on brain images, this is known as the clinical-radiolo…
Latent Space Arc Therapy Optimization
Noah Bice, Mohamad Fakhreddine, Ruiqi Li +5
Volumetric modulated arc therapy planning is a challenging problem in high-dimensional, non-convex optimization. Traditionally, heuristics such as fluence-map-optimization-informed…
SIRNet: Understanding Social Distancing Measures with Hybrid Neural Network Model for COVID-19 Infectious Spread
Nicholas Soures, David Chambers, Zachariah Carmichael +5
The SARS-CoV-2 infectious outbreak has rapidly spread across the globe and precipitated varying policies to effectuate physical distancing to ameliorate its impact. In this study,…
MM for Penalized Estimation
Zhu Wang
Penalized estimation can conduct variable selection and parameter estimation simultaneously. The general framework is to minimize a loss function subject to a penalty designed to g…
Convolutional neural network models for cancer type prediction based on gene expression
Milad Mostavi, Yu-Chiao Chiu, Yufei Huang +1
Background Precise prediction of cancer types is vital for cancer diagnosis and therapy. Important cancer marker genes can be inferred through predictive model. Several studies hav…
Generalized Inverse Optimization through Online Learning
Chaosheng Dong, Yiran Chen, Bo Zeng
Inverse optimization is a powerful paradigm for learning preferences and restrictions that explain the behavior of a decision maker, based on a set of external signal and the corre…
Predicting drug response of tumors from integrated genomic profiles by deep neural networks
Yu-Chiao Chiu, Hung-I Harry Chen, Tinghe Zhang +5
The study of high-throughput genomic profiles from a pharmacogenomics viewpoint has provided unprecedented insights into the oncogenic features modulating drug response. A recent s…
GSAE: an autoencoder with embedded gene-set nodes for genomics functional characterization
Hung-I Harry Chen, Yu-Chiao Chiu, Tinghe Zhang +3
Bioinformatics tools have been developed to interpret gene expression data at the gene set level, and these gene set based analyses improve the biologists' capability to discover f…
Visualization and Correction of Automated Segmentation, Tracking and Lineaging from 5-D Stem Cell Image Sequences
Eric Wait, Mark Winter, Chris Bjornsson +5
Results: We present an application that enables the quantitative analysis of multichannel 5-D (x, y, z, t, channel) and large montage confocal fluorescence microscopy images. The i…
Evaluation of Competing J domain:Hsp70 Complex Models in Light of Existing Mutational and NMR Data
Rui Sousa, Jianwen Jiang, Eileen M. Lafer +4
Ahmad et al. recently presented an NMR-based model for a bacterial DnaJ J domain:DnaK(Hsp70):ADP complex(1) that differs significantly from the crystal structure of a disulfide lin…
Latent rank change detection for analysis of splice-junction microarrays with nonlinear effects
Jonathan Gelfond, Lee Ann Zarzabal, Tarea Burton +3
Alternative splicing of gene transcripts greatly expands the functional capacity of the genome, and certain splice isoforms may indicate specific disease states such as cancer. Spl…
Evaluation of the Neutron Background in a Direct WIMP Detector with Neutron Veto System Based on Gd-doped Liquid Scintillator
Ye Xu, XiangPan Ji, ZeLong Liu +3
A direct WIMP (Weakly Interacting Massive Particle) detector with a neutron veto system is designed to better reject neutrons. Two experimental configurations are studied in the pr…
Towards Experimental Tests of Quantum Effects in Cytoskeletal Proteins
Andreas Mershin, Hugo Sanabria, John H. Miller +7
It has become increasingly evident that fabrication of novel biomaterials through molecular self-assembly is going to play a significant role in material science and possibly the i…
Quantitative Imaging of Protein-Protein Interactions by Multiphoton Fluorescence Lifetime Imaging Microscopy using a Streak camera
R. V. Krishnan, A. Masuda, V. E. Centoze +1
Fluorescence Lifetime Imaging Microscopy (FLIM) using multiphoton excitation techniques is now finding an important place in quantitative imaging of protein-protein interactions an…
Development of a Multiphoton Fluorescence Lifetime Imaging Microscopy (FLIM) system using a Streak Camera
R. V. Krishnan, H. Saitoh, H. Terada +2
We report the development and detailed calibration of a multiphoton fluorescence lifetime imaging system (FLIM) using a streak camera. The present system is versatile with high spa…
Probing subtle fluorescence dynamics in cellular proteins by streak camera based Fluorescence Lifetime Imaging Microscopy
R. V. Krishnan, Eva Biener, Jian-Hua Zhang +2
We report the cell biological applications of a recently developed multiphoton fluorescence lifetime imaging microscopy system using a streak camera (StreakFLIM). The system was ca…
Discrete stochastic modeling of calcium channel dynamics
Markus Baer, Martin Falcke, Herbert Levine +1
We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabi…