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9 papers · 1 filter
Genetically Improved BarraCUDA
W. B. Langdon, Brian Yee Hong Lam
BarraCUDA is a C program which uses the BWA algorithm in parallel with nVidia CUDA to align short next generation DNA sequences against a reference genome. The genetically improved…
Misrepair mechanism: a mechanism essential for individual adaptation, species adaptation and species evolution
Jicun Wang-Michelitsch, Thomas M. Michelitsch
In Misrepair-accumulation theory, we have proposed a Misrepair mechanism for interpreting aging. However, Misrepair mechanism is also important in biological adaptation. Misrepair…
Cell transformation in tumor-development: a result of accumulation of Misrepairs of DNA through many generations of cells
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Development of a tumor is known to be a result of accumulation of DNA changes in somatic cells. However, the processes of how DNA changes are produced and how they accumulate in so…
Misrepair mechanism in the development of atherosclerotic plaques
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on siz…
Development of aging changes: self-accelerating and inhomogeneous
Jicun Wang-Michelitsch, Thomas Michelitsch
Aging changes including age spots and atherosclerotic plaques develop in an inhomogeneous and accelerated manner. For understanding this phenomenon, some aging changes are analyzed…
Aging as a process of accumulation of Misrepairs
Jicun Wang-Michelitsch, Thomas Michelitsch
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept…