4.8k citations
- University of CambridgeGB16 papers
- Centre National de la Recherche ScientifiqueFR6 papers
- Institut Jean Le Rond d'AlembertFR6 papers
- Cambridge University Hospitals NHS Foundation TrustGB4 papers
- Imperial College LondonGB4 papers
- University College LondonGB4 papers
- AstraZeneca (United Kingdom)GB3 papers
- Genomics (United Kingdom)GB3 papers
- Medical University of ViennaAT3 papers
- NIHR Cambridge Biomedical Research CentreGB3 papers
- Sorbonne UniversitéFR3 papers
- University of DundeeGB3 papers
4 papers · 1 filter
Misrepair mechanism: a mechanism essential for individual adaptation, species adaptation and species evolution
Jicun Wang-Michelitsch, Thomas M. Michelitsch
In Misrepair-accumulation theory, we have proposed a Misrepair mechanism for interpreting aging. However, Misrepair mechanism is also important in biological adaptation. Misrepair…
Cell transformation in tumor-development: a result of accumulation of Misrepairs of DNA through many generations of cells
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Development of a tumor is known to be a result of accumulation of DNA changes in somatic cells. However, the processes of how DNA changes are produced and how they accumulate in so…
Misrepair mechanism in the development of atherosclerotic plaques
Jicun Wang-Michelitsch, Thomas M. Michelitsch
Atherosclerosis is a disease characterized by the development of atherosclerotic plaques (APs) in arterial endothelium. The APs in part of an arterial wall are inhomogeneous on siz…
Aging as a process of accumulation of Misrepairs
Jicun Wang-Michelitsch, Thomas Michelitsch
We recently introduced Misrepair-accumulation theory as an interpretation on aging mechanism. For better understanding this theory, we discuss here in more details the new concept…