Cross-correlated TIRF/AFM shows Self-assembled Synthetic Myosin Filaments are Asymmetric - Implications for Motile Filaments

Andre E. X. Brown, Alina Hategan, Daniel Safer +2

Myosin-II's rod-like tail drives filament assembly with a head arrangement that should generate equal and opposite contractile forces on actin--if one assumes that the filament is…