activity
20122023
most citedA mathematical model of the metabolic and perfusion effects on cortical spreading depression

73 citations · 138 across the 15 of their papers we have counts for

collaborators

15 papers

stat.ME2023★ 1 cited

Interpretable (not just posthoc-explainable) heterogeneous survivor bias-corrected treatment effects for assignment of postdischarge interventions to prevent readmissions

Hongjing Xia, Joshua C. Chang, Sarah Nowak +4

We used survival analysis to quantify the impact of postdischarge evaluation and management (E/M) services in preventing hospital readmission or death. Our approach avoids a specif…

stat.ME2022

Autoencoded sparse Bayesian in-IRT factorization, calibration, and amortized inference for the Work Disability Functional Assessment Battery

Joshua C. Chang, Carson C. Chow, Julia Porcino

The Work Disability Functional Assessment Battery (WD-FAB) is a multidimensional item response theory (IRT) instrument designed for assessing work-related mental and physical funct…

cs.CY2022★ 2 cited

Interpretable (not just posthoc-explainable) medical claims modeling for discharge placement to prevent avoidable all-cause readmissions or death

Joshua C. Chang, Ted L. Chang, Carson C. Chow +5

We developed an inherently interpretable multilevel Bayesian framework for representing variation in regression coefficients that mimics the piecewise linearity of ReLU-activated d…

cs.LG2020★ 2 cited

Sparse encoding for more-interpretable feature-selecting representations in probabilistic matrix factorization

Joshua C. Chang, Patrick Fletcher, Jungmin Han +5

Dimensionality reduction methods for count data are critical to a wide range of applications in medical informatics and other fields where model interpretability is paramount. For…

stat.AP2020★ 1 cited

Regularized Bayesian calibration and scoring of the WD-FAB IRT model improves predictive performance over marginal maximum likelihood

Joshua C. Chang, Julia Porcino, Elizabeth K. Rasch +1

Item response theory (IRT) is the statistical paradigm underlying a dominant family of generative probabilistic models for test responses, used to quantify traits in individuals re…

cs.LG2019★ 4 cited

Probabilistically-autoencoded horseshoe-disentangled multidomain item-response theory models

Joshua C. Chang, Shashaank Vattikuti, Carson C. Chow

Item response theory (IRT) is a non-linear generative probabilistic paradigm for using exams to identify, quantify, and compare latent traits of individuals, relative to their peer…

q-bio.QM2017★ 1 cited

High-resolution reconstruction of cellular traction-force distributions: the role of physically motivated constraints and compressive regularization

Joshua C. Chang, Yanli Liu, Tom Chou

We develop a method to reconstruct, from measured displacements of an underlying elastic substrate, the spatially dependent forces that cells or tissues impart on it. Given newly a…

stat.ME2017★ 19 cited

Predictive Bayesian selection of multistep Markov chains, applied to the detection of the hot hand and other statistical dependencies in free throws

Joshua C. Chang

Consider the problem of modeling memory effects in discrete-state random walks using higher-order Markov chains. This paper explores cross validation and information criteria as pr…

stat.ME2017

Determination of hysteresis in finite-state random walks using Bayesian cross validation

Joshua C. Chang

Consider the problem of modeling hysteresis for finite-state random walks using higher-order Markov chains. This Letter introduces a Bayesian framework to determine, from data, the…

stat.ME2017

Asymptotic convergence in distribution of the area bounded by prevalence-weighted Kaplan-Meier curves using empirical process modeling

Aaron Heuser, Minh Huynh, Joshua C. Chang

The Kaplan-Meier product-limit estimator is a simple and powerful tool in time to event analysis. An extension exists for populations stratified into cohorts where a population sur…

physics.data-an2015★ 16 cited

Bayesian field theoretic reconstruction of bond potential and bond mobility in single molecule force spectroscopy

Joshua C. Chang, Pak-Wing Fok, Tom Chou

Quantifying the forces between and within macromolecules is a necessary first step in understanding the mechanics of molecular structure, protein folding, and enzyme function and p…

cond-mat.soft2015★ 7 cited

Regulatory inhibition of biological tissue mineralization by calcium phosphate through post-nucleation shielding by Fetuin-A

Joshua C. Chang, Robert M. Miura

In vertebrates, insufficient availability of calcium and phosphate ions in extracellular fluids leads to loss of bone density and neuronal hyper-excitability. To counteract this pr…

physics.data-an2013★ 8 cited

A path-integral approach to Bayesian inference for inverse problems using the semiclassical approximation

Joshua C Chang, Van Savage, Tom Chou

We demonstrate how path integrals often used in problems of theoretical physics can be adapted to provide a machinery for performing Bayesian inference in function spaces. Such inf…

cs.CV2012★ 4 cited

Iterative graph cuts for image segmentation with a nonlinear statistical shape prior

Joshua C. Chang, Tom Chou

Shape-based regularization has proven to be a useful method for delineating objects within noisy images where one has prior knowledge of the shape of the targeted object. When a co…

q-bio.NC2012★ 73 cited

A mathematical model of the metabolic and perfusion effects on cortical spreading depression

Joshua C. Chang, K. C. Brennan, Dongdong He +4

Cortical spreading depression (CSD) is a slow-moving ionic and metabolic disturbance that propagates in cortical brain tissue. In addition to massive cellular depolarization, CSD a…