178 citations · 806 across the 18 of their papers we have counts for
18 papers
Learning noisy tissue dynamics across time scales
Ming Han, John Devany, Michel Fruchart +2
Tissue dynamics play a crucial role in biological processes ranging from inflammation to morphogenesis. However, these noisy multicellular dynamics are notoriously hard to predict.…
Learning via mechanosensitivity and activity in cytoskeletal networks
Deb S. Banerjee, Martin J. Falk, Margaret L Gardel +3
In this work we show how a network inspired by a coarse-grained description of actomyosin cytoskeleton can learn - in a contrastive learning framework - from environmental perturba…
Motor crosslinking augments elasticity in active nematics
Steven A. Redford, Jonathan Colen, Jordan L. Shivers +8
In active materials, uncoordinated internal stresses lead to emergent long-range flows. An understanding of how the behavior of active materials depends on mesoscopic (hydrodynamic…
Measuring response functions of active materials from data
Mehdi Molaei, Steven A. Redford, Wen-hung Chou +4
From flocks of birds to biomolecular assemblies, systems in which many individual components independently consume energy to perform mechanical work exhibit a wide array of strikin…
Zyxin is all you need: machine learning adherent cell mechanics
Matthew S. Schmitt, Jonathan Colen, Stefano Sala +5
Cellular form and function emerge from complex mechanochemical systems within the cytoplasm. No systematic strategy currently exists to infer large-scale physical properties of a c…
Learning to learn: Non-equilibrium design protocols for adaptable materials
Martin J. Falk, Jiayi Wu, Ayanna Matthews +5
Evolution in time-varying environments naturally leads to adaptable biological systems that can easily switch functionalities. Advances in the synthesis of environmentally-responsi…
Catapulting of topological defects through elasticity bands in active nematics
Nitin Kumar, Rui Zhang, Steven A. Redford +2
Active materials are those in which individual, uncoordinated local stresses drive the material out of equilibrium on a global scale. Examples of such assemblies can be seen across…
Machine learning active-nematic hydrodynamics
Jonathan Colen, Ming Han, Rui Zhang +10
Hydrodynamic theories effectively describe many-body systems out of equilibrium in terms of a few macroscopic parameters. However, such hydrodynamic parameters are difficult to der…
Structuring Stress for Active Materials Control
Rui Zhang, Steven A. Redford, Paul V. Ruijgrok +8
Active materials are capable of converting free energy into mechanical work to produce autonomous motion, and exhibit striking collective dynamics that biology relies on for essent…
Nucleation and shape dynamics of model nematic tactoids around adhesive colloids
Nicholas B. Ludwig, Kimberly Weirich, Eli Alster +4
Recent experiments have shown how nematically-ordered tactoid shaped actin droplets can be reorganized and divided by the action of myosin molecular motors. In this paper, we consi…
Stress relaxation in F-actin solutions by severing
S. Arzash, P. M. McCall, J. Feng +2
Networks of filamentous actin (F-actin) are important for the mechanics of most animal cells. These cytoskeletal networks are highly dynamic, with a variety of actin-associated pro…
Tunable structure and dynamics of active liquid crystals
Nitin Kumar, Rui Zhang, Juan J. de Pablo +1
Active materials are capable of converting free energy into directional motion, giving rise to striking dynamical phenomena. Developing a general understanding of their structure i…
Interplay of Structure, Elasticity and Dynamics in Actin-Based Nematic Materials
Rui Zhang, Nitin Kumar, Jennifer Ross +2
Achieving control and tunability of lyotropic materials has been a long-standing goal of liquid crystal research. Here we show that the elasticity of a liquid crystal system consis…
Encoding Mechano-Memories in Actin Networks
Sayantan Majumdar, Louis C. Foucard, Alex J. Levine +1
Understanding the response of complex materials to external force is central to fields ranging from materials science to biology. Here, we describe a novel type of mechanical adapt…
Force generation by Myosin II Filaments in Compliant Networks
Samantha Stam, Jon Alberts, Margaret L. Gardel +1
Myosin II isoforms with varying mechanochemistry and filament size interact with filamentous actin (F-actin) networks to generate contractile forces in cells. How their properties…
Observation and Characterization of the Vestige of the Jamming Transition in a Thermal 3D System
Thomas A. Caswell, Zexin Zhang, Margaret L. Gardel +1
We study the dependence of the pair-correlation function, , and particle mobility on packing fraction in a dense three-dimensional packing of soft colloids made of poly N-iso…
Contractile units in disordered actomyosin bundles arise from F-actin buckling
Martin Lenz, Todd Thoresen, Margaret L. Gardel +1
Bundles of filaments and motors are central to contractility in cells. The classic example is striated muscle, where actomyosin contractility is mediated by highly organized sarcom…
Requirements for contractility in disordered cytoskeletal bundles
Martin Lenz, Margaret L. Gardel, Aaron R. Dinner
Actomyosin contractility is essential for biological force generation, and is well understood in highly organized structures such as striated muscle. Additionally, actomyosin bundl…