1 citations · 1 across the 2 of their papers we have counts for
3 papers
Optimal designs for enzyme inhibition kinetic models
Kirsten Schorning, Holger Dette, Katrin Kettelhake +1
In this paper we present a new method for determining optimal designs for enzyme inhibition kinetic models, which are used to model the influence of the concentration of a substrat…
Optimal designs for active controlled dose finding trials with efficacy-toxicity outcomes
Holger Dette, Katrin Kettelhake, Kirsten Schorning +2
Nonlinear regression models addressing both efficacy and toxicity outcomes are increasingly used in dose-finding trials, such as in pharmaceutical drug development. However, resear…
Designing dose finding studies with an active control for exponential families
Holger Dette, Katrin Kettelhake, Frank Bretz
In a recent paper Dette et al. (2014) introduced optimal design problems for dose fnding studies with an active control. These authors concentrated on regression models with normal…