Molecular Mechanism of Transition from Catch-Bond to Slip-Bond in Fibrin

Rustem I. Litvinov, Olga Kononova, Farkhad Maksudov +4

The lifetimes of non-covalent A:a knob-hole bonds in fibrin probed with the optical trap-based force-clamp first increases ("catch bonds") and then decreases ("slip bonds") with in…